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Study evaluates the therapeutic effect of an antibody in NSCLC

Le 5 juin 2017, 05:35 dans Humeurs 0

Patients who have previously treated, advanced or metastatic non-small-cell lung cancer (NSCLC) tend to have bad prognosis. Atezolizumab, a fully humanized, engineered monoclonal antibody against the protein programmed cell death-ligand 1 (PD-L1), shows effective against several types of tumors, including NSCLC. Now a study demonstrates that some patients with previously treated NSCLC indeed benefit from atezolizumab treatment even after their disease has progressed. The study, led by scientists at Kaiser Permanente Medical Center, Virginia Cancer Specialists Research Institute, Genentech, University Hospitals KU Leuven, Paul Sabatier University, Sungkyunkwan University School of Medicine, and Lungenfachklinik Immenhausen, is published 9 March 2016 in The Lancet.

Lung cancer is the second most common cancer and the leading cause of cancer death. NSCLC accounts for up to 85% of all lung cancers, and it is usually divided into adenocarcinoma, squamous cell carcinoma , and large cell carcinoma. It usually grows and spreads more slowly than small cell lung cancer, and it produces no symptoms until the disease until the disease is well advanced. Metastatic, or stage IV NSCLC, has a five-year survival rate of only about 1%. Early diagnosis is crucial for better outcomes. Although there are a variety of treatment options for patients such as surgery, radiofrequency ablation, radiation therapy, chemotherapy, targeted therapies, and immunotherapy. In most cases, more than one treatment approach is used. But for those with advanced disease, more effective therapies are still in need.

For this work, the team evaluated the efficacy and safety of atezolizumab versus docetaxel (a chemotherapy medication used to treat many different cancers) in previously treated NSCLC. They study enrolled patients with NSCLC who progressed on post-platinum chemotherapy. 142 patients were given atezolizumab, and 135 patients received docetaxel. Results showed that patients receiving the antibody atezolizumab had better survival compared to patients in the docetaxel group. By analyzing PD-L1 expression, the researchers demonstrated this increasing improvement in overall survival was related to increasing PD-L1 expression.

Taken together, the study shows that the antibody drug atezolizumab markedly prolonged survival of patients with previously treated NSCLC, and that PD-L1 immunohistochemistry expression could help predict which patients would benefit from atezolizumab treatment. Atezolizumab has already been approved by the FDA for bladder cancer. Findings of this study indicates that this anti-PD-L1 antibody could also be used in other types of cancer. (Cusabio offers Biotin conjugated antibody for scientific research.)



Three Dog Night

Le 28 avril 2017, 04:37 dans Humeurs 0


 Three handsome male dogs are walking down the street when they see a beautiful, enticing, female poodle. The three male dogs fall all over themselves in an effort to be the one to reach her first, but end up arriving in front of her at the same time. The males are speechless before her beauty Karson Choi, slobbering on themselves and hoping for just a glance from her in return.

 Aware of her charms and her obvious effect on the three suitors, she decides to be kind and tells them "The first one who can use the words "liver" and "cheese" together in an imaginative, intelligent sentence can go out with me."

 The sturdy, muscular black Lab speaks up quickly and says "I love liver and cheese."

 "Oh, how childish," said the Poodle. "That shows no imagination or intelligence whatsoever wedding event management."

 She turned to the tall, shiny Golden Retriever and said, "How well can you do?" "Ummmm...I HATE liver and cheese," blurts the Golden Retriever.

 "My, my," said the Poodle. "I guess it's hopeless. That's just as dumb as the Lab's sentence."

 She then turns to the last of the three dogs and says, "How about you, little guy?"

 The last of the three, tiny in stature but big in fame and finesse, is the Taco Bell chihuahua. He gives her a smile, a sly wink, turns to the Golden Retriever and the Lab and says Karson Choi...

Secrets, Lies and Love

Le 31 août 2016, 06:16 dans Humeurs 0

March 12, 2007 issue - A few years ago, just as her father was about to disappear into the fog of dementia, journalist Lucinda Franks stumbled upon a small box in a corner of his dilapidated apartment business center. The contents shocked her. Beneath some mysterious maps and crumpled foreign bank notes, she found a military cap embellished with the raised metal insignia of an eagle, a skull and crossbones—and a swastika. Franks knew little about her father's military service during World War II, and had always sensed that he was hiding something. Now questions consumed her. "Was my sphinx-like father presenting one character and living another?" she writes in her new memoir, "My Father's Secret War." "Whose side was he really on?" When she pressed for an explanation, her father refused to talk, citing a decades-old pledge of secrecy corporate apartment.
But after years of detective work and long conversations with her ailing father, Franks eventually pieced together most of his story. Fluent in German, he was a spy and occasionally an assassin. The Nazi cap was part of his disguise as a member of the Waffen SS, worn the night he broke into a Gestapo headquarters and killed a guard while looking for files with the names of people wanted by the Nazis. Near the end of his life serviced apartments in hong kong, he finally tells Franks he kept the hat because of the "death's head" insignia: "I never wanted to forget who these German soldiers really were."

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